Research

· Scaling analysis of mass spectral data

· Fragment ion mass defect labeling

· Mass spectrometry of modified proteins both chemically and biologically

· Membrane proteins

Recent Publications

1. A. A. Ramos, H. Yang, L. E. Rosen, X. Yao “Tandem Parallel Fragmentation of Peptides for Mass Spectrometry,” Analytical Chemistry, 2006; ASAP Web Release Date: 18-Aug-2006.

2. M. Heller, H. Mattou, C. Menzel, X. Yao “Trypsin catalyzed ¹⁶O-to-¹⁸O exchange for comparative proteomics: comparison on tandem mass spectrometry using MALDI-TOF, ESI-QqTOF and ESI-ion trap mass spectrometers,” Journal of American Society for Mass Spectrometry, 2003, 14(7), 704.

3. X. Yao, C. Afonso, C. Fenselau “Dissection of proteolytic ¹⁸O labeling: endoprotease-catalyzed ¹⁶O-to-¹⁸O exchange of truncated peptide substrates,” Journal of Proteome Research, 2003, 2, 147.

4. K. Shefcheck, X. Yao, C. Fenselau “Fractionation of cytosolic proteins on an immobilized heparin column,” Analytical Chemistry, 2003, 75, 1691.

5. K. J. Reynolds, X. Yao, C. Fenselau “Proteolytic ¹⁸O labeling for comparative proteomics: evaluation of endoprotease Glu-C as the catalytic agent,” Journal of Proteome Research, 2002, 1, 28.

6. X. Yao, A. Freas, J. Ramirez, P.A. Demirev, C Fenselau “Proteolytic ¹⁸O labeling for comparative proteomics: model studies with two serotypes of adenovirus,” Analytical Chemistry, 2001, 73, 2836.

7. X. Yao, M.A. Gold, R. M. Pollack “Transition state imbalance in proton transfer from phenyl ring substituted 2-tetralones to acetate ion,” Journal of the American Chemical Society, 1999, 121, 6220.

8. X. Yao, R. M. Pollack “Electronic effects on enol acidity and keto-enol equilibrium constants for ring-substituted 2-tetralones,” Canadian Journal of Chemistry, 1999, 77, 634.