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The University of Connecticut
School of Pharmacy, Room 535
Storrs, CT 06269
Tel : 860-486-3852
E-mail: jose.manautou@uconn.edu
Area of Speciality:
Mechanisms of Target Organ Toxicity, with special emphasis on the liver,
Hepatic Detoxification and Disposition Mechanisms, and
Hepatotoxicants and Interference affecting susceptibility to chemical injury.
Biographical Note:
Professor Manautou received a PhD in Pharmacology and Toxicology from Purdue University and a BS in Pharmacy from the University of Puerto Rico. He is a member of the editorial boards of Toxicology and Applied Pharmacology and Toxicological Sciences. As a faculty member at UConn, he has a special interest in studying the mechanistic basis for protection against acetaminophen hepatotoxicity by repeated dosing with peroxisome proliferators. Another area of investigation deals with the role of transport proteins in the hepatobiliary disposition of xenobiotics and their metabolites. He also investigates the changes in expression of hepatic transporters in response to drug-induced liver injury and its functional consequences.
Selected Publications:
Current Grants:
Howard Hughes Medical Institute: “ Regulation of Hepatic Multidrug Resistance Protein 3 (Mrp3) During Oxidative Stress.” Predoctoral Fellowship in Biomedical Sciences to graduate student Lauren Aleskunes
University of Connecticut Research Foundation: “Regulation of Transporter Expression by Nrf2 during Drug-Induced liver Injury”, J. Manautou (P.I.)
01 DK069557-01 “Transporter Expression in Response to Hepatotoxicants”, J. Manautou (P.I.)
Pfizer, Inc: “Expression of Murine and Human Hepatic Transport Proteins During Drug-Induced Liver Injury”, J. Manautou (P.I.)
NIH PA03-026 “Minority Programs for the Society of Toxicology Meeting, J. Manautou (Co P.I.)
Environmental Protection Agency “ Undergraduate Education Program for the 2006 Society of Toxicology Annual Meeting”, J. Manautou (P.I.)
Recent Publications:
Guo, G.L., Moffit, J.S., Nicol, C. Ward, J.M., Aleksunes, L.M., Kliewer, S.A., Manautou, J.E. , Gonzalez, F.J. (2006). Enhanced acetaminophen toxicity by activation of pregnane X receptor. Toxicologist , 90 (1) 1321.
Goedken, M., Aleksunes, L.M., Manautou, J.E. (2006). Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury.Toxicologist , 90 (1) 1367 .
Lickteig, A., Fisher, C.D., Augustine, L.M., Aleksunes, L.M., Besselsen, A., Bhattacharyya, A., Manautou, J.E. , Cherrington, N.J. (2006). Altered hepatic and renal efflux transport in diet-induced models of non-alcoholic fatty liver disease. Toxicologist , 90 (1) 2400.
Silva, V.M., Hennig, G.E., and Manautou, J.E. (2006). Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice, in preparation. Tox. Letters , 160:204-211.
Aleksunes, L.M., Goedken, M.J., and Manautou, J.E . (2006). Up-regulation of NAPD(H) quinone oxidoreductase 1 during human liver injury. World J. Gatroenterol. , 12:1937-40.
Aleksunes, L.M., Scheffer, G.L, Jakowski, A., Pruimboom-Brees, I.M., Manautou, J.E. (2006). Coordinated expression of multidrug resistance associated proteins (Mrps) in mouse liver during toxicant–induced injury, Toxicol. Sci. , 89:370-379. Featured in Toxicological Highlights; Toxicol. Sci. 89:341-351.
Moffit, J.S., Aleksunes, L.M., Maher, J.M., Scheffer, G.L., Klaassen, C.D., and Manautou, J.E. (2006). Induction of Hepatic Transporters Mrp3 and Mrp4 by clofibrate is regulated by PPAR alpha, submitted, J. Pharmacol. Exper. Ther., 317:537-45.
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