Welcome to the Cole Group Home Page

Our laboratory uses biophysical approaches to characterize macromolecular interactions that regulate important biological processes. We are particularly interested in defining host-virus interactions that are ammenable to therapeutic intervention. A major project in our group is to define how the antiviral kinase PKR is activated by RNA and inhibited by viral regulators. We rely heavily on analytical ultracentrifugation experiments performed at our facility at the University of Connecticut, but we also make extensive use of fluorescence, microcalorimetry, light scattering and small angle X-ray and neutron scattering.