Courses

MCB 4008/5008: Techniques of Biophysical Chemistry

Syllabus
   Data collection and instrument design
   Treatment of experimental data
   Analytical ultracentrifugation
   Light scattering
   Hydrodynamic modeling of macromolecules
   Interactions of biological molecules
   Isothermal titration calorimetry
   Vapor pressure osmometry
   Surface plasmon resonance
   Single molecular methods

MCB 5012: Foundations of structural Biochemistry (with Victoria Robinson)

Syllabus
Biological macromolecules
   Membrane proteins
   Lipds and detergents
   Nucleic acids
   Protein-nucleic acid interactions
Experimental methods for analysis of biomolecular structure and interactions
   CD
   Fluorescence
   Mass spectroscopy
   Light scattering
   Isothermal titration calorimetry
   Analytical ultracentrifugation
Enzymes
   Principles of catalysis and structural features
   Kinetics and mechanisms
   Regulation: protein kinases

MCB 3007/5003: Introduction to biophysical chemistry

Syllabus
Conservation of energy: 1st Law
   Energy exchanges
   State Variables
   Transitions and phase changes
   Chemical reactions
Entropy increases: 2nd law
   Entropy is not conserved
   Molecular interpretation
Gibbs (free) energy and phase equilibria
   Phase transitions and biological systems
   Mixtures and solutions
   Colligative Properties
Gibbs (free )energy and chemical equilibria
   Thermodynamics of chemical reactions
   Effects of conditions
   Biochemical applications
   Membrane transport
   Biological electron transfer reactions
Molecular motion and transport properties
   Kinetic molecular theory
   Diffusion and sedimentation
   Kinetics and the rates of reactions
   Rate laws and reaction mechanisms
   Temperature dependence
   Transition state theory
   Fast reactions
Integrating it all: Photosynthetic energy conversion