| 222.
Medical Cytogenetics
Both semesters. Four credits. Two 2-hour lectures.
Prerequisite: MCB 203 and MCB 200 or 213; all of which may be concurrent.
Open to students in the Diagnostic Genetic Sciences Program; others who
have met the prerequisites.
Birth defects, prenatal assessment, cell culture
and harvest, staining and banding techniques, mechanisms of numerical and
structural chromosome abnormality, numerical syndromes, duplication and
deletion syndromes, the sex chromosomes, sex chromosome abnormalities,
human chromosome nomenclature, mosaicism, genetic imprinting, cancer
cytogenetics, molecular cytogenetic testing. |
| 223. Laboratory in Cytogenetics
Both semesters. Three credits. One 3-hour
laboratory period and one 2-hour discussion. Four additional laboratory
sessions are required during the first half of the semester. Prerequisite:
DGS 222 which may be taken concurrently. Open only to students enrolled in
the Diagnostic Genetic Sciences Program; others with consent of
instructor.
Human chromosome morphology and identification,
aseptic technique, lymphocyte culture and harvest, chromosome banding,
karotyping and microscopic analysis of normal and abnormal
cases. |
| 224.
Cancer Cytogenetics
Offered Summer I. Variable credits.
Prerequisite: DGS 223. Open only to students enrolled in the
Diagnostic Genetic Sciences Program; others with consent of
instructor.
Chromosome instability syndromes, genetic basis of
cancer, cytogenetics of solid tumors and hematologic malignancies, and
nomenclature of acquired changes. |
| 234. Diagnostic Molecular Technologies
Both semesters. Three credits. Prerequisite: MCB
200 or 213; and MLS 208 or MCB 211 which may be taken concurrently. Open
only to students enrolled in the Diagnostic Genetic Sciences
Program.
DNA and RNA diagnostic technologies used in
clinical settings; clinical applications in prenatal diagnosis; cancer
management, transplantation, paternity testing, forensic medicine and
microbiology. |
| 235. Laboratory in Molecular Diagnostics
Both semesters. Four credits. Prerequisite: DGS 234
or MLS 217 which may be taken concurrently. Open only to students enrolled
in the Diagnostic Genetic Sciences Program.
DNA isolation, blotting techniques, fluorescent in
situ hybridization, polymerase chain reaction and Genprobe
assay. |
| 242.
Chromosome Imaging
First semester and Summer Session I. Two credits.
Two hours of lecture and 1 hour of discussion. Prerequisites: DGS 222 and
223. Open only to DGS majors; others with consent of instructor. Fall
offering open only to DGS students with a Spring Clinical.
Theory and techniques of bright field microscopy,
black and white film processing and printing, and computerized imaging for
karyotype production. |
| 246. Contemporary Issues in Human Genetics
Both semesters. Three credits. Prerequisite: DGS
223. Open only to students enrolled in the Diagnostic Genetic Sciences
Program; others with consent of the instructor.
Advanced karotyping and microscopic diagnosis;
report writing; historical perspective; recent advances and future trends
in human genetics; ethical issues of genetic research, technological
advances, genetic diagnosis and the practice of medical genetics;
exploration of the lay person's understanding of human genetics and
genetic diagnosis. |
| 260.
Blotting Methods
Both semesters. Six credits. Prerequisite: In order
to enroll in this course, a student must have earned a "C" or better in
DGS 234 and 235. Open only to DGS molecular certificate
students.
Practicum experience with blotting technologies
stressing complete Southern analysis. |
| 261.
Amplification Methods
Both semesters. Six credits. Prerequisite: In order
to enroll in this course, a student must have earned a "C" or better in
DGS 234 and 235. Open only to DGS molecular certificate
students.
Practicum experience in DNA and/or RNA
amplification stressing polymerase chain reaction. |
| 273. Research in Molecular Genetics
Both semesters. One credit. Prerequisites: In order
to enroll in this course, a student must have earned a "C" or better in AH
241W, DGS 234 and DGS 235. Open only to students enrolled in the Molecular
Diagnostic Sciences Certificate Program; others with consent of the
instructor.
Design and implementation of a research project in
molecular genetics. |
| 275. In Situ Hybridization Methods
Both semesters. Two credits. Prerequisites: In
order to enroll in this course, a student must have earned a "C" or better
in DGS 234 and 235. Open only to DGS molecular certificate
students.
Practicum in fluorescence in situ
hybridization or other in situ hybridization
techniques. |
| 276. Topics in Molecular Genetics
Both semesters. Two credits. Prerequisite: In order
to enroll in this course, a student must have earned a "C" or better in
DGS 234 and DGS 235. Open only to students enrolled in the Molecular
Diagnostic Sciences Certificate Program; others with consent of the
instructor.
Exploration of an individual area of interest in
molecular genetics. |
| 277.
Mutagenesis
Both semesters. Two credits. Prerequisite:In order
to enroll in this course, a student must have earned a "C" or better in
DGS 234 and DGS 235. Open only to students enrolled in the Molecular
Diagnostic Sciences Certificate Program; others with consent of the
instructor.
Practicum experience in mutagenesis, including Ames
assays and mammalian mutagenesis assays. |
| 278. DNA
Sequencing
Both semesters. Two credits. Prerequisite:In order
to enroll in this course, a student must have earned a "C" or better in
DGS 234 and DGS 235. Open only to students enrolled in the Molecular
Diagnostic Sciences Certificate Program; others with consent of the
instructor.
Practicum experience in DNA
sequencing. |
| 279. Microbiological Applications of Molecular
Diagnostics
Both semesters. Two credits. Prerequisite: In order
to enroll in this course, a student must have earned a "C" or better in
DGS 234 and DGS 235. Open only to students enrolled in the Molecular
Diagnostic Sciences Certificate Program; others with consent of the
instructor.
Practicum experience in the application of
molecular technologies to microbiology. |
| 280. Bone Marrow Cytogenetics
Both semesters. Two credits. Prerequisite: In order
to enroll in the course, the student must have earned a "C" or better in
DGS 222, DGS 223 and DGS 224. Open only to Diagnostic Genetic Sciences
majors.
Culture, harvest, banding and analysis of leukemic
bone marrow samples; chromosomal abnormalities associated with hematologic
malignancies. |
| 281. Peripheral Blood Cytogenetics
Both semesters. Four credits. Prerequisite: In
order to enroll in this course, the student must have earned a "C" or
better in DGS 222 and DGS 223. Open only to Diagnostic Genetic Sciences
majors.
Culture, harvest, banding and analysis of
peripheral blood samples. |