First semester. Three credits. Two lectures and one problem session. Prerequisite: BIOL 107. Open to sophomores. Strausbaugh

Principles of genetics as applied to humans. Focus on modern methods of molecular genetics.

Second semester. Three credits. Recommended preparation: MCB 200 or 210 or 229. Open to sophomores. Hightower

Basic mechanisms of genetic information transfer in eukaryotic cells from DNA to folded and assembled proteins. Regulation of transcription, translation, DNA replication, and the cell cycle.

Either semester. Four credits. Three class periods and one 3-hour laboratory period. Prerequisite: CHEM 141 or 244. (CHEM 244 may also be corequisite.) Open to sophomores. Not open for credit to students who have passed MCB 204. May substitute for MCB 204 only if taken with MCB 226 and with permission of the Department Head to satisfy the biochemistry requirement of the molecular and cell biology major.

The structure, chemistry, and metabolism of carbohydrates, lipids and proteins. Enzyme function and kinetics, energy metabolism, and structure and function of nucleic acids. A survey course for students of agriculture, general biology, medical technology, nursing, and pharmacy. Molecular and Cell Biology majors, biophysics majors, and other students desiring a more intensive introduction or considering advanced course work in biochemistry or molecular biology should take MCB 204.

First semester. Five credits. Four class periods and one 3-hour laboratory. Prerequisite or corequisite: CHEM 244. Recommended preparation: MCB 210 or MCB 229. Not open for credit to students who have passed MCB 203. Teschke

The structure and function of biological macromolecules. The metabolism of carbohydrates, lipids, amino acids, proteins and nucleic acids. The regulation of metabolism and biosynthesis of biological macromolecules. An in-depth introduction intended for students planning to take advanced course work in biochemistry, biophysics, or other areas of molecular biology.

Second semester, alternate years. Two credits. Prerequisite: MCB 203 or 204, or consent of instructor. Albert

A thorough analysis of the inter-relationships of metabolic pathways in connection with human health and disease, including inherited metabolic diseases and the role of hormones in metabolic pathways.

First semester. Three credits. Prerequisite: BIOL 107 or CHEM 128, or consent of instructor. Yeagle

An introduction to principles underlying the structure and function of the molecules guiding life processes. These principles will be applied to proteins, DNA/RNA and membranes as well as to the energetics of life processes.

Second semester. Three credits. Prerequisite: CHEM 243; MATH 114Q or 116Q; PHYS 122, 132 or 142; or consent of instructor.

Energetics and kinetics of metabolic reactions. Interactions of electromagnetic radiation and biological macromolecules. Formation and energetics of supramolecular structures. The basis of selected techniques of molecular biology, such as DNA hybridization, radioimmune assays. DNA melting and thermal transitions in polymers, thermodynamics, analysis of reactions, binding theory, cooperative interactions.

Second semester. Three credits. Prerequisite: MCB 207, or CHEM 263, or consent of instructor. Braswell

The characterization of biological macromolecules (i.e. proteins and nucleic acids) in solution is important to the biotechnology and pharmoceutical industries. This course deals with hydrodynamic techniques (i.e. diffusion, electrophoresis, sedimentation, light scattering, and viscosity) for molecular size and shape, and spectroscopic methods (such as circular dichroism) for more detailed structure.

Second semester. Three credits. Prerequisite or corequisite: MCB 204 or 203 or consent of instructor. Knox

Correlation of three-dimensional molecular architecture with biochemical function in proteins, nucleic acids, and large assemblies such as viruses and ribosomes. Folding motifs and domains; molecular ancestry/homology; molecular recognition at the atomic level, as in DNA/protein complexes; structural basis of enzyme specificity and catalysis. Structure prediction from sequence; principles of structure determination by x-ray diffraction, NMR and CD spectroscopies, and electron microscopy. X-ray laboratory and graphics demonstrations.

First semester. Three credits. Prerequisite: BIOL 107. This course is intended to be taken before MCB 203 or 204(Biochemistry). Open to sophomores. Knecht/Lee

Structural organization of cells and the molecular basis of dynamic cellular processes, with emphasis on eukaryotic cells. Topics include protein targeting, vesicle trafficking, cytoskeleton, cell-cell interactions in tissues, and the molecular basis of related human diseases.

First semester. Three credits. Prerequisite: BIOL 107. Recommended preparation: MCB 210. Lynes

An introduction to the genetic, biochemical, and cellular mechanisms of the immune system. This course will address basic aspects of immune function, and will examine abnormal immune function associated with cancer, autoimmune disease, AIDS, and other immunological abnormalities.

Second semester. Three credits. Prerequisite: MCB 200 or 213. Recommended preparation: MCB 204 or 203. R. O'Neill

Methods and applications of genetic engineering, including gene manipulation and transfer techniques in prokaryotes and eukaryotes. Emphasis on applications of recombinant DNA technology in the
elucidation of gene function. Consideration of recent technological developments in molecular genetics, such as cloning, gene therapy, the patenting and release of genetically engineered organisms, and societal issues related to these developments.

Second semester. Four credits. Three class periods and 2-hour laboratory. Prerequisite: BIOL 108 or 110, or MCB 200 or equivalent, and CHEM 128. Open to sophomores. Zhang

Survey of genetic theory and applications of genetic analysis. Model genetic systems in animals, plants, and microbes.

Second semester. Two credits. One fifty minute lecture period and one three hour laboratory session. Prerequisite:  MCB 200. O'Neill

An introductory laboratory course in principles and techniques of DNA manipulation and identification. Course simulates independent research, using modern molecular genetics techniques.

First semester. Three credits. One 1-hour lecture and two 3-hour laboratory periods. Open only with consent of instructor. Recommended preparation: MCB 204, MCB 212 or 217. Not open for credit to students who have passed MCB 230. Reiter

Modern methods in molecular genetics arranged to meet a research goal. Use of polymerase chain reaction, bacteriophage library screening, molecular cloning, nucleic acid hybridizations, and DNA sequence determinations to isolate and characterize a eukaryotic gene.

First semester. Four credits. Three lecture periods and one 2-hour discussion. Prerequisite: MCB 229.Noll

Molecular genetics of bacteria, archaebacteria, and their viruses. Transcription and replication of DNA, transformation, transduction, conjugation, genetic mapping, mutagenesis, regulation of gene expression, genome organization.

First semester. Three credits. Open to sophomores. May not be counted toward the biology major. 

The principles of heredity and their implications for society.

(Formerly offered as MCB 222.) First semester. Four credits. Three class periods and library research. Open to sophomores. May not be counted toward the biology major.

Second semester. Three credits. Prerequisite: BIOL 107. Recommended preparation: MCB 210 and 213 or 200, which may be taken concurrently. Krider

Principles of embryogenesis, pattern formation, and cell differentiation. The focus will be on molecular and cellular aspects of development in several experimental systems, including the mouse, nematode, fruit fly, and frog.

Second semester. Three credits. Two 3-hour laboratory periods and a discussion/recitation period. Prerequisite or corequisite: MCB 219, or six credits of college biology and consent of instructor. Not open for credit to students who have passed MCB 223.

Analysis of principles of morphogenesis and differentiation.

(Formerly offered as MCB 223.) Second semester. Four credits. Two 3-hour laboratory periods and two discussion/recitation periods. Prerequisite or corequisite: MCB 219, or two semesters of college biology and consent of instructor. 

First semester. Three credits. Recommended preparation: At least one 200 level course in MCB. Open to sophomores. Gogarten

Evolution of biomolecules, and application to molecular data analysis and the design of new molecules. Topics include prebiotic chemistry, origin of cells, selfish genes, molecular innovations, data bank
searches, alignment of sequence and 3-D protein structures. Course includes lectures, discussions and computer lab exercises.

First semester. Three credits. Recommended preparation: one 200 level course in MCB. Kendall

Molecular basis of human disease and strategies for developing therapeutic treatments. Applications of genetic, cellular, and biochemical information in treating disease states. Especially appropriate for students interested in biomedical research and the health profession.

Second semester. Three credits. Two 3 1/2 hour laboratory/lecture periods. Prerequisite: MCB 213.  Prerequisite or corequisite: MCB 217 or 229 . Open only with consent of instructor.

Experiments in bacterial genetics, emphasizing genetic manipulations using modern techniques for mutant isolation, DNA characterization and cloning. These include the use of transposons, DNA isolation, restriction analysis, gel electrophoresis, PCR and DNA sequencing.

Second semester. Four credits. One 1-hour lecture and two 4-hour laboratories. Prerequisite: Either MCB 204, or MCB 203 with consent of instructor. Teschke

Theory and application of modern techniques for separation and characterization of biological macromolecules, including several types of liquid chromatography, liquid scintillation spectro-photometry, and SDS polyacrylamide gel electrophoresis. Instruction in writing a scientific paper.

Either semester. Four credits. Three lecture periods and one 2-1/2-hour laboratory period. Prerequisite or corequisite: CHEM 141 or 243. Recommended preparation: BIOL 107 or equivalent. Open to sophomores. Gage, Terry, Vinopal

Biology of microorganisms, especially bacteria. Cellular structure, physiology, genetics, and interactions with higher forms of life. Laboratory familiarizes students with methodology of microbiology and aseptic techniques.

Summer session. Two credits. One 4-hour laboratory. Prerequisite: MCB 200 or 213. Prerequisite or corequisite:  MCB 229. Not open for credit to students who have passed MCB 215.

Theory and application of techniques used in biotechnology and molecular genetics, including recombinant DNA procedures, gel electrophoresis and blot analysis.

First semester. Three credits. One 1-hour lecture and two 3-hour laboratories. Recommended preparation: MCB 200 or 204 or 210 or 213 or 229. Braswell

Introduction to the use of microcomputers in molecular biology, emphasizing commercially available applications software, both general (spreadsheet, word processing, database, graphics) and specialized (DNA and protein sequence database manipulation, molecular modeling, data acquisition, others).

Second semester. Four credits. Two class periods and two 2-hour laboratory periods. Prerequisite: MCB 229. Recommended preparation: MCB 204 (or 203).

A detailed study of microbial genera, emphasizing species which are important in diseases of man and animals and which have special public health significance. Diagnostic methods include some standard serological procedures.

First semester. Four credits. Two class periods and two 2-hour laboratory periods. Prerequisite: MCB 229. Recommended preparation: MCB 204 (or 203). Benson

A study of the biology, physiology, and genetics of microorganisms useful in industry, agriculture, and selected environmental processes.

(Also offered as MARN 236.) Second semester. Three credits. Two lecture-discussion class periods and one 2-hour laboratory period for which field trips may be substituted. Offered at the Avery Point Campus. Prerequisite: MCB 229, or consent of instructor.

A general survey of the taxonomy, physiology, and ecology of marine microorganisms.

Second semester. Four credits. Two lecture periods and two 3-hour laboratory/discussion periods. Prerequisite: MCB 229 or consent of instructor. Recommended preparation: MCB 204 (or 203). Leadbetter

A study of the ecophysiology of diverse bacterial types with particular emphasis on the activities of bacteria in situ. Investigative laboratory includes individual projects.

First semester. Three credits. Open only with consent of instructor. Recommended preparation: one 200's course in MCB. With a change in content, may be repeated for credit. Leadbetter

Discussion of current research in molecular and cell biology. Focus on microbes as agents of environmental change.

Second semester. Three credits. Three lecture periods. Prerequisite: MCB 229. Recommended preparation: MCB 204 or 210. Marcus

Biological, biochemical, physical, and genetic characteristics of viruses, with an emphasis on molecular and quantitative aspects of virus-cell interactions.

Summer session. Two credits. Prerequisite: MCB 259.

Recent advances in in vitro, hydroponic and controlled environment culture of plants.

First session. Three credits. Three 1-hour class periods. Recommended preparation: BIOL 108 (or 110) and CHEM 128. 

Functioning of plants in relation to external and internal factors. The course integrates pertinent findings from cell biology, genetics and molecular biology. Topics include photosynthesis, long distance and trans-membrane transport, selected biochemical pathways, phytohormones, photomorphogenisis and movements in plants.

Summer. Two credits. Consent of instructor. Recommended preparation: MCB 259.

Either semester. Three credits. With a change of topic, may be repeated for credit. Prequisites and recommended preparation vary.

Second semester. Three credits. Recommended preparation: a course in genetics. Strausbaugh

DNA analysis in forensic science, with emphasis on molecular genetic technology in criminal investigations and issues surrounding the use of DNA evidence. Team-taught with forensic practitioners.

Either semester. Three credits. Hours by arrangement. Prerequisite or corequisite: Three credits of MCB 299. Open only with consent of instructor and department honors commitee. Not limited to honors students.

Designed for the advanced undergraduate who is pursuing a special problem as an introduction to independent investigation. Research and writing of a thesis.

Either or both semesters. Credits and hours by arrangement. Open only with consent of instructor. May be repeated for credit with a change of topic.

Either semester. Credits and hours by arrangement. With a change in content, may be repeated for credit. Prerequisites and recommended preparation vary.

Either or both semesters. Credits and hours by arrangement. Open only with consent of instructor and the department honors committee. May be repeated for credit with change in topic.

Designed for the advanced undergraduate student who desires to pursue a special problem as an introduction to independent investigation.