| 210. Introduction
to Biomedical Engineering.
(Also offered as ECE 272.) First semester. Three credits. Prerequisite:
BIOL 107. Corequisite: PHYS 151Q and MATH 210Q. Open to sophomores. Fox
Survey of the ways engineering and medical science interact. The art
and science of medicine, and the process of medical diagnosis and treatment.
Diagnostic instrumentation and measurements including medical imaging.
Introduction to bioelectric phenomena, biomechanics, and biomaterials.
Biochemical engineering. Computers in medicine.
Molecular medicine and biotechnology. |
| 221. Introduction
to Biochemical Engineering
(Also offered as CHEG 273 and as ENVE 283.) Second semester. Three credits.
Recommended preparation: CHEG 224 and 251.
Enzyme and fermentation technology; microbiology, biochemistry, and
cellular concepts; biomass production; equipment design, operation, and
specification; design of biological reactors; separation processes for
bio-products. |
| 223. Fermentation
and Separation Technologies Laboratory
Second semester. Three credits. One class and two 3-hour laboratories.
Prerequisite: BME 221.
Introduction to techniques used for industrial mass culture of prokaryotic
and eukaryotic cells, and methods used to extract useful products from
these cultures. Metabolic processes, energentics, growth kinetics and nutrition
of microorganisms. Synthesis of cellular material and end products. Heat
exchange, oxygen transfer, pH control, sterilization and design of fermentors.
Culture of eukaryotic cell mass. Immobilized enzyme and cell reactors.
Product recovery methods of precipitation centrifugation, extraction filtration
and chromatography. |
| 251. Biosystem Analysis
Second semester. Three credits. Prerequisite: BME 210. This course and
ECE 202 may not be both taken for credit.
Fourier analysis, LaPlace analysis and Z-transforms. Techniques for
generating quantitative mathematical models of physiological control systems;
the behavior of physiological control systems using both time and frequency
domain methods. |
| 252. Biomedical
Engineering Measurements
First semester. Four credits. Prerequisite: BME 210 or ECE 272.
A lecture and laboratory course that covers fundamentals of biomedical
measurement and patient safety. Measurements of physical quantities by
means of electronic instruments, mechanical devices and biochemical processes.
Analysis of measurement systems using mathematical models. Methods of measuring
signals in the presence of noise. Use of computers in measurement systems. |
| 253. Physiological
Control Systems
Semester by arrangement. Three credits. Prerequisite: BME 251 or ECE
232.
Analysis of human physiological control systems and regulators through
the use of mathematical models. Identification and linearization of system
components. Systems interactions, stability, noise, and the relation of
system malfunction to disease. The analysis and design of feedback systems
to control physiological states through the automatic administration of
drugs. |
| 255. Bioinstrumentation
Either semester. Three credits. Prerequisites: ECE 201 or ECE 220.
Modeling, analysis, design, and operation of transducers, sensors, and
electrodes, for physiological systems; operational and instrumentation
amplifiers for bioelectric event signal conditioning, interfacing and
processing; A/D converters and hardware and software principles as
related to sampling, storing, processing, and display of biosignals and
digital computers. |
| 261. Biomechanics
Second semester. Four credits. Prerequisites: BME 210.
A lecture and laboratory course that covers mechanics of bone and soft
tissue. Biosolids and biofluids. Simple and combined stress and strain,
torsion and flexure. Tissue strength and constitutive equations. Fatigue
and fracture resistance of bone. Synovial joint mechanics. Friction and
wear, gears, pins, clutches, joints, rivets, screws and other joining elements
and their structural interactions. Material selections for the biomedical
design. |
| 271. Biomaterials
Second semester. Four credits. Prerequisites: MMAT 201, BME 210,
BME
261.
A lecture and laboratory course that examines the structure and properties
of materials used in surgical implants and medical devices. Consideration
is given to issues of mechanical properties, biocompatibility, degradation
of materials by biological systems, and biological response to artificial
materials. Particular attention will be given to the materials for the
total hip prosthesis, dental restoration, and implantable medical devices. |
| 272. Advanced Biomaterials
Semester by arrangement. Hours by arrangement. Three credits. Prerequisites:
BME
210 and
BME 271.
The strategies and fundamental bioengineering design criteria behind
the development of cell-based tissue substitutes, artificial skin, muscle,
tendons, bone, and extracorporeal systems that use either synthetic materials
or hybrid (biological-synthetic) systems. Topics include biocompatibility,
biological grafts, gene-therapy-transfer, and bioreactors. |
| 290. Biomedical
Engineering Design I
Both semesters. Three credits. Prerequisites: This course is taken by
seniors in the semester before BME 291.
Discussion of the design process; project statement, specifications
project planning, scheduling and division of responsibility, ethics in
engineering design, safety, environmental considerations, economic constraints,
liability, manufacturing, and marketing. Projects are
carried out using a team-based approach. Selection and analysis of
a design project to be undertaken in BME 291 is carried out. Written progress
reports, a proposal, an interim project report, a final report, and oral
presentations are required. |
| 291. Biomedical
Engineering Design II
Both semesters. Three credits. Prerequisite: BME 290.
Design of a device, circuit system, process, or algorithm. Team solution
to an engineering design problem as formulated in BME 290, from first concepts
through evaluation and documentation. Written progress reports, a final
report, and oral presentation are required. |